Amoxil Oral

Generic Name: amoxicillin (Oral route)

a-mox-i-SIL-in

Commonly used brand name(s)

In the U.S.

• Amoxicot


• Amoxil


• DisperMox


• Moxatag


• Moxilin


• Trimox

In Canada

• Amoxil Pediatric


• Apo-Amoxi


• Apo-Amoxi Sugar-Free


• Gen-Amoxicillin


• Med Amoxicillin


• Novamoxin


• Novamoxin Reduced Sugar


• Nu-Amoxi


• Riva-Amoxicillin


• Scheinpharm Amoxicillin


• Zimamox

Available Dosage Forms:

• Tablet


• Tablet, Chewable


• Tablet for Suspension


• Powder for Suspension


• Tablet, Extended Release


• Capsule

Therapeutic Class: Antibiotic

Pharmacologic Class: Penicillin, Aminopenicillin

Uses For Amoxil

Amoxicillin is used to treat bacterial infections in many different parts of the body. It is also used with other medicines (e.g., clarithromycin, lansoprazole) to treat H. pylori infection and duodenal ulcers.

Amoxicillin belongs to the group of medicines known as penicillin antibiotics. It works by killing the bacteria and preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Amoxil

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of amoxicillin in children. However, newborns and infants 3 months of age and younger have incompletely developed kidney functions, which may need a lower dose of this medicine.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amoxicillin in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving amoxicillin.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Methotrexate


• Venlafaxine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Desogestrel


• Dienogest


• Drospirenone


• Estradiol Cypionate


• Estradiol Valerate


• Ethinyl Estradiol


• Ethynodiol Diacetate


• Etonogestrel


• Khat


• Levonorgestrel


• Medroxyprogesterone Acetate


• Mestranol


• Norelgestromin


• Norethindrone


• Norgestimate


• Norgestrel


• Probenecid


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to penicillins or cephalosporin antibiotics (e.g., cefaclor, cefadroxil, cephalexin, Ceftin®, or Keflex®) or


• Mononucleosis (viral infection)—Should not be used in patients with these conditions.

• Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Phenylketonuria (PKU)—The chewable tablet contains phenylalanine, which can make this condition worse.

Proper Use of amoxicillin

This section provides information on the proper use of a number of products that contain amoxicillin. It may not be specific to Amoxil. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine with or without food.

For patients using the oral liquid:

• Shake the bottle well before each use. Measure the dose with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.


• You may mix the oral liquid with a baby formula, milk, fruit juice, water, ginger ale, or another cold drink. Be sure the child drinks all of the mixture immediately.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules, powder for suspension, and tablets):
  
  • For bacterial infections:
    
    • Adults, teenagers, and children weighing 40 kilograms (kg) or more—250 to 500 milligrams (mg) every 8 hours, or 500 to 875 mg every 12 hours.
    
    
    • Children and infants older than 3 months of age weighing less than 40 kg—Dose is based on body weight and must be determined by your doctor. The usual dose is 20 to 40 milligrams (mg) per kilogram (kg) of body weight per day, divided and given every 8 hours, or 25 to 45 mg per kg of body weight per day, divided and given every 12 hours.
    
    
    • Infants 3 months of age and younger—Dose is based on body weight and must be determined by your doctor. The usual dose is 30 mg per kg of body weight per day, divided and given every 12 hours.
    
    
  
  
  • For treatment of gonorrhea:
    
    • Adults, teenagers, and children weighing 40 kilograms (kg) or more—3-grams (g) taken as a single dose.
    
    
    • Children 2 years of age and older weighing less than 40 kg—Dose is based on body weight and must be determined by your doctor. The usual dose is 50 milligrams (mg) per kilogram (kg) of body weight per day, combined with 25 mg per kg of probenecid, taken as a single dose.
    
    
    • Children younger than 2 years of age—Use is not recommended.
    
    
  
  
  • For treatment of H. pylori infection:
    
    • Adults—
      
      • Dual therapy: 1000 milligrams (mg) of amoxicillin and 30 mg of lansoprazole, each given three times a day (every 8 hours) for 14 days.
      
      
      • Triple therapy: 1000 mg of amoxicillin, 500 mg of clarithromycin, and 30 mg of lansoprazole, all given two times a day (every 12 hours) for 14 days.
      
      
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

You may store the oral liquid in the refrigerator. Throw away any unused medicine after 14 days. Do not freeze.

Precautions While Using Amoxil

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause a serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a skin rash; itching; shortness of breath; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, mouth, or throat after you or your child receive this medicine.

Amoxicillin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

In some young patients, tooth discoloration may occur while using this medicine. The teeth may appear to have brown, yellow, or gray stains. To help prevent this, brush and floss your teeth regularly or have a dentist clean your teeth.

Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control along with your birth control pills. Other forms include a condom, a diaphragm, or a contraceptive foam or jelly.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Amoxil Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach cramps or tenderness


• back, leg, or stomach pains


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloating


• blood in the urine


• bloody nose


• chest pain


• chills


• clay-colored stools


• cough


• dark urine


• diarrhea


• diarrhea, watery and severe, which may also be bloody


• difficulty with breathing


• difficulty with swallowing


• dizziness


• fast heartbeat


• feeling of discomfort


• fever


• general body swelling


• headache


• heavier menstrual periods


• hives or welts


• increased thirst


• inflammation of the joints


• itching


• joint or muscle pain


• loss of appetite


• muscle aches


• nausea or vomiting


• nosebleeds


• pain


• pain in the lower back


• pain or burning while urinating


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rash


• red, irritated eyes


• redness, soreness, or itching skin


• shortness of breath


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• sores, welting, or blisters


• sudden decrease in the amount of urine


• swollen, lymph glands


• tenderness


• tightness in the chest


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight loss


• vomiting of blood


• watery or bloody diarrhea


• wheezing


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Bad, unusual, or unpleasant (after) taste


• change in taste

Incidence not known

• Agitation


• black, hairy tongue


• changes in behavior


• confusion


• convulsions


• discoloration of the tooth (brown, yellow, or gray staining)


• dizziness


• sleeplessness


• trouble with sleeping


• unable to sleep


• white patches in the mouth or throat or on the tongue


• white patches with diaper rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

lomustine

loe-MUS-teen

Oral route(Capsule)

Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to bleeding and overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of lomustine. Blood counts should be monitored weekly for at least 6 weeks after a dose. At the recommended dosage, courses of lomustine should not be given more frequently than every 6 weeks. The bone marrow toxicity of lomustine is cumulative and therefore dosage adjustment must be considered on the basis of nadir blood counts from prior dose .

Commonly used brand name(s)

In the U.S.

• Ceenu

Available Dosage Forms:

• Capsule

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Alkylating Agent

Chemical Class: Nitrosourea

Uses For lomustine

Lomustine is used alone or in combination with other medicines to treat brain tumors, Hodgkin's disease, and other kinds of cancer. lomustine belongs to the group of medicines known as alkylating agents.

Lomustine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by lomustine, other effects may occur. Some of these may be serious and must be reported to your doctor. Other effects (e.g., hair loss) may not be serious, but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with lomustine, you and your doctor should talk about the good lomustine will do as well as the risks of using it.

lomustine is available only with your doctor's prescription.

Before Using lomustine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lomustine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lomustine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of lomustine have not been performed in the pediatric population. However, pediatric-specific problems that would limit the usefulness of lomustine in children are not expected.

Geriatric

No information is available on the relationship of age to the effects of lomustine in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving lomustine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking lomustine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using lomustine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rotavirus Vaccine, Live

Using lomustine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adenovirus Vaccine Type 4, Live


• Adenovirus Vaccine Type 7, Live


• Bacillus of Calmette and Guerin Vaccine, Live


• Influenza Virus Vaccine, Live


• Measles Virus Vaccine, Live


• Mumps Virus Vaccine, Live


• Rotavirus Vaccine, Live


• Rubella Virus Vaccine, Live


• Smallpox Vaccine


• Typhoid Vaccine


• Varicella Virus Vaccine


• Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of lomustine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia (low red cells in the blood) or


• Bone marrow problems or


• Leukopenia (low white cells in the blood) or


• Lung disease or


• Thrombocytopenia (low platelets in the blood)—May make these conditions worse.

• Chickenpox, including recent exposure, or


• Herpes zoster (shingles) or


• Infection—May decrease the ability to fight an infection.

• Kidney disease—Effects may be increased because of slower removal from the body.

Proper Use of lomustine

Take lomustine only as directed by your doctor. Do not take more or less of it than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

In order that you receive the proper dose of lomustine, there may be two or more different types of capsules in the container. This is not an error. It is important that you take all of the capsules in the container at the same time so you receive the right dose of the medicine.

Be careful while handling lomustine. Wear gloves when touching the capsules containing lomustine. Do not break, crush, or open the capsules. If any of lomustine gets on your skin or in your nose or mouth, wash the area with soap and water right away. If the medicine gets in your eyes, wash them with water right away and call your doctor.

lomustine is sometimes given together with other medicines. If you are using a combination of medicines, make sure that you take each one at the right time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right time.

Nausea and vomiting often occur with lomustine, but usually last less than 24 hours. Loss of appetite may last for several days. lomustine is best taken on an empty stomach at bedtime, so it will cause less stomach upset. Ask your doctor for other ways to lessen these side effects.

If you vomit shortly after taking a dose of lomustine, check with your doctor. You may be told to take the dose again.

Dosing

The dose of lomustine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lomustine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For brain tumors or Hodgkin's disease:
    
    • Adults and children—Dose is based on body surface area and must be determined by your doctor. The usual dose is 130 milligrams (mg) per square meter (m(2)) of body surface area, given as a single dose every 6 weeks. Your doctor may adjust your dose if needed.
    
    
  
  

Missed Dose

lomustine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using lomustine

It is very important that your doctor check your progress at regular visits to make sure that lomustine is working properly. Blood tests may be needed to check for unwanted effects.

Using lomustine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor right away if you have any of the following symptoms: fever, chills, dry cough, sore throat, confusion, shortness of breath, swelling of the feet or lower legs, unusual bleeding or bruising, or yellow eyes or skin.

While you are being treated with lomustine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Lomustine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Lomustine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.


• Avoid contact sports or other situations where bruising or injury could occur.

lomustine Side Effects

Along with their needed effects, medicines like lomustine can sometimes cause unwanted effects such as blood problems, loss of hair, and other side effects; these are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bleeding gums


• chest pain


• shortness of breath


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• unusual bleeding or bruising


• unusual tiredness or weakness

Less common

• Awkwardness


• black, tarry stools


• blood in the urine or stools


• confusion


• cough or hoarseness


• decrease in urination


• fever or chills


• lower back or side pain


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• slurred speech


• swelling of the feet or lower legs


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness

Incidence not known

• Abdominal or stomach pain or tenderness


• bone pain


• change in frequency of urination or amount of urine


• clay colored stools


• dark urine


• decreased appetite


• dizziness


• drowsiness


• dry mouth


• headache


• increased blood pressure


• increased thirst


• itching


• loss of appetite


• nausea or vomiting


• skin rash


• weight gain


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Darkening of the skin


• diarrhea

Incidence not known

• Blurred vision


• changes in patterns and rhythms of speech


• confusion about identity, place, and time


• decreased vision


• eye pain


• hair loss or thinning of the hair


• shakiness and unsteady walk


• swelling or inflammation of the mouth


• trouble with speaking


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: lomustine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More lomustine resources

• Lomustine Side Effects (in more detail)
• Lomustine Dosage
• Lomustine Use in Pregnancy & Breastfeeding
• Lomustine Drug Interactions
• Lomustine Support Group
• 0 Reviews for Lomustine - Add your own review/rating

• lomustine Concise Consumer Information (Cerner Multum)


• Lomustine Professional Patient Advice (Wolters Kluwer)


• Lomustine Monograph (AHFS DI)


• CeeNU Prescribing Information (FDA)


• CeeNU MedFacts Consumer Leaflet (Wolters Kluwer)

Compare lomustine with other medications

• Anaplastic Oligodendroglioma
• Brain Tumor
• Hodgkin's Lymphoma

Expectuss Liquid

carbetapentane citrate, and guaifenesin

Dosage Form: liquid
Expectuss Liquid

Description:

Expectuss Liquid is an alcohol-free, sugar-free, purple liquid for oral administration having a grape odor and flavor.


Each Teaspoon (5 mL) Contains:

CARBETAPENTANE CITRATE 20 mg

GUAIFENESIN 75 mg

CLINICAL PHARMACOLOGY:

Carbetapentane citrate is a centrally acting non-narcotic antitussive.


Guaifenesin is an expectorant. Its action increases the output of respiratory tract fluid by reducing

adhesiveness and surface tension. Sinus and bronchial drainage is improved and dry, nonproductive

coughs become more productive and less frequent.

INDICATIONS AND USAGE:

For temporary relief of non-productive cough accompanying respiratory tract congestion associated with

the common cold, influenza, sinusitis, and bronchitis.

CONTRAINDICATIONS:

Expectuss Liquid is contraindicated in infants, newborns, and in patients with a known

hypersensitivity to any of the components. It is also contraindicated in patients on MAO inhibitor therapy.

WARNINGS:

A persistent cough may be a sign of a serious condition. If cough persists for more than one week

or tends to recur, or is accompanied by fever, rash, or persistent headache, patient reevaluation

should be considered.

PRECAUTIONS: DRUG INTERACTIONS:

Guaifenesin may produce an increase in urinary 5-hydroxy-indoleacetic acid and may therefore interfere

with the interpretation of this test for the diagnosis of carcinoid syndrome. It may also falsely elevate the

 VMA test for catechols. Administration of this drug should be discontinued 48 hours prior to the collection

of urine specimens for such tests.

CARCINOGENESIS, MUTAGENESIS, AND IMPAIRMENT OF FERTILITY:

No adequate and well controlled studies have been conducted to determine whether the components

of Expectuss Liquid have a potential for carcinogenesis, mutagenesis, or impairment of fertility.

PREGNANCY:

Pregnancy Category C: Animal reproduction studies have not yet been conducted with this product.

It is not known whether it can cause fetal harm when administered to a pregnant woman or can affect

reproduction capacity. This product should not be administered to pregnant women.

NURSING MOTHERS:

Due to the possible passage of the ingredients into breast milk, this product should not be given to nursing mothers.

ADVERSE REACTIONS:

Guaifenesin is well tolerated and has a wide margin of safety. Side effects are generally

mild and infrequent. Nausea and vomiting are the most common side effects. Dizziness,

headache, and rash (including urticaria) have been reported rarely.

OVERDOSAGE: SIGNS AND SYMPTOMS:

Incidence of acute toxicity with guaifenesin is low and over dosage is unlikely to produce

serious toxic effects. In laboratory animals no toxicity resulted when guaifenesin was

administered by stomach tube in doses up to 5 grams/kg.


TREATMENT: Treatment of the signs and symptoms of overdosage is symptomatic and

supportive. The patient should be induced to vomit, even if emesis has occurred spontaneously.

Pharmacologic vomiting by the administration of ipecac syrup is a preferred method, however,

vomiting should not be induced in patients with impaired consciousness. Precautions against

aspiration must be taken, especially in infants and children. Following emesis, any drug

remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water.

DOSAGE AND ADMINISTRATION:

Expectuss Liquid is administered orally as follows:


Adults: 1-2 teaspoonfuls every 4-6 hours or as directed by a physician.

Children 6-12 years of age: 1 teaspoonful every 4-6 hours or as directed by a physician.

Children 6 years of age and under: as directed by a physician.

How supplied:

16 fluid ounce bottles NDC# 23359-003-16


KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN.

IN CASE OF ACCIDENTAL OVERDOSAGE, CONTACT A POISON CONTROL

CENTER AND SEEK PROFESSIONAL ASSISTANCE IMMEDIATELY.


Store between 59o-86oF (15o-30oC).


DISPENSE IN TIGHT, LIGHT RESISTANT CONTAINERS WITH CHILD RESISTANT CLOSURES

AS DEFINED IN THE USP/NF.


Manufactured for:


Centurion Labs, LLC.

Birmingham, AL 35243


For Professional Use

Consult a Physician


Rev. 7/09

PRODUCT PACKAGING:

The packaging below represents the labeling currently used:


NDC 23359-003-16


Expectuss Liquid


ANTITUSSIVE/EXPECTORANT


Each 5 mL (1 teaspoon) contains:

Carbetapentane Citrate..... 20 mg

Guaifenesin...................... 75 mg


SUGAR FREE

ALCOHOL FREE


Rx Only


1 PINT (473 mL)


CENTURION LABS



Side Panels:


USUAL DOSAGE:


Adults:

1-2 teaspoonfuls every 4 to 6 hours or as directed by a physician.


Children 6-12 years of age:

1 teaspoonful every 4 to 6 hours or as directed by a physician.


Children 2-6 years of age:

1/2 teaspoonful every 4-6 hours or as directed by a physician.


Children under 2 years of age:

Use as directed by a physician.


See package insert for complete prescribing information.


PHARMACIST:

Dispense in a tight, light-resistant container with a child-resistant closure as defined in the USP/NF.


This container is not intended for dispensing to the patient.


DO NOT USE IF FOIL SEAL IS BROKEN OR MISSING!


INDICATIONS AND USAGE:

For temporary relief of non-productive cough accompanying respiratory tract congestion associated

with the common cold, influenza, sinusitis, and bronchitis.


STORAGE:

Store at controlled room temperature, 59o-86oF (15o-30oC).


Keep this and all drugs out of the reach of children.


In case of accidental overdosage, contact a poison control center and seek professional

assistance immediately.


Manufactured For:

Centurion Labs, LLC.

Birmingham, AL 35243


Rev. 07/07

EXPECTUSS  LIQUID carbetapentane citrate, and guaifenesin  liquid

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 23359-003 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Carbetapentane Citrate (Carbetapentane) Carbetapentane Citrate 20 mg  in 5 mL Guaifenesin (Guaifenesin) Guaifenesin 75 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor GRAPE Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 23359-003-16 473 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		11/30/2009

Labeler - Centurion Labs, LLC (806756461)

Revised: 12/2009Centurion Labs, LLC

More Expectuss Liquid resources

• Expectuss Liquid Side Effects (in more detail)
• Expectuss Liquid Dosage
• Expectuss Liquid Use in Pregnancy & Breastfeeding
• Expectuss Liquid Drug Interactions
• Expectuss Liquid Support Group
• 0 Reviews for Expectuss - Add your own review/rating

Compare Expectuss Liquid with other medications

• Cough

Adios Tablets

1. Name Of The Medicinal Product

ADIOS™ TABLETS

2. Qualitative And Quantitative Composition

Butternut 20 mg; Dandelion Root 30 mg; Dry extract Boldo (4:1) 34 mg; Dry extract of Fucus (5:1) 45 mg.

3. Pharmaceutical Form

Peachy orange biconvex sugar-coated tablets.

4. Clinical Particulars

4.1 Therapeutic Indications

A herbal remedy traditionally used as an aid to slimming.

4.2 Posology And Method Of Administration

To be taken by mouth.

Adults (16 years and above) and elderly: One tablet three or four times a day at mealtimes.

This product should be taken as part of a calorie-controlled diet.

4.3 Contraindications

Do not use if allergic to any of the ingredients.

Do not use if under 16 years of age.

4.4 Special Warnings And Precautions For Use

Because fucus is a mild thyroid stimulator containing iodine, this medicine may be inappropriate for patients with a thyroid condition - particularly until the normal thyroid state has been restored.

Because it contains lactose and sucrose, patients with rare hereditary problems of galactose or fructose intolerance, glucose-galactose malabsorption, the Lapp lactase deficiency or sucrase-isomaltase insufficiency should not take this medicine.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Adios can theoretically have an effect on anticoagulant treatments. Closer monitoring of such patients by their doctor/clinic is advised if they take Adios.

4.6 Pregnancy And Lactation

Not recommended.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Diarrhoea may occur particularly in those receiving high doses.

4.9 Overdose

Discontinue medicine.

Treat any diarrhoea with fluid replacement.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Fucus is a mild thyroid stimulator. Boldo, Dandelion and Juglans (Butternut Bark) are cholagogues.

5.2 Pharmacokinetic Properties

No special information.

5.3 Preclinical Safety Data

No special information.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Sucrose; Lactose; Sodium Starch Glycollate; Talc; Pre-gelatinised Starch; Magnesium Stearate; Kaolin; E171 (Titanium Dioxide); Red Iron Oxide 17266; Yellow Iron Oxide 17268.

6.2 Incompatibilities

None.

6.3 Shelf Life

36 months.

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

White plastic container with tamper-evident cap, containing 100 tablets.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Diomed Herbals

Tatmore Place, Gosmore

Hitchin, Herts SG4 7QR, UK

8. Marketing Authorisation Number(S)

17418/0005.

9. Date Of First Authorisation/Renewal Of The Authorisation

11 May 2007.

10. Date Of Revision Of The Text

May 2010.

Promacet

Generic Name: acetaminophen and butalbital (a SEET a MIN oh fen and bue TAL bi tal)

Brand Names: Bupap, Cephadyn, Marten-Tab, Phrenilin, Phrenilin Forte, Promacet, Sedapap

What is Promacet (acetaminophen and butalbital)?

Acetaminophen is a pain reliever and fever reducer.

Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache.

The combination of acetaminophen and butalbital is used to treat tension headaches. This medicine is not for treating headaches that come and go.

Acetaminophen and butalbital may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Promacet (acetaminophen and butalbital)?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Before you take acetaminophen and butalbital, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease, a stomach or intestinal disorder, or a history of drug or alcohol addiction.

Butalbital may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What should I discuss with my healthcare provider before taking Promacet (acetaminophen and butalbital)?

Do not use this medication if you are allergic to acetaminophen (Tylenol) or butalbital, or if you have porphyria. Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Butalbital may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

To make sure you can safely take acetaminophen and butalbital, tell your doctor if you have any of these other conditions:

• liver disease;


• kidney disease;


• 
  

  a stomach or intestinal disorder; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

FDA pregnancy category C. It is not known whether acetaminophen and butalbital will harm an unborn baby, but it can cause seizures in a newborn if the mother takes the medication late in pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Acetaminophen and butalbital can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.

How should I take Promacet (acetaminophen and butalbital)?

Take exactly as prescribed by your doctor. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Take this medicine with a full glass of water. Do not stop using acetaminophen and butalbital suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using this medication.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using acetaminophen and butalbital.

If you need surgery, tell the surgeon ahead of time that you are using acetaminophen and butalbital. You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Butalbital is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since acetaminophen and butalbital is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and butalbital can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include extreme drowsiness, confusion, fainting, shallow breathing, or no breathing.

What should I avoid while taking Promacet (acetaminophen and butalbital)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Promacet (acetaminophen and butalbital) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fast or pounding heart rate, feeling short of breath;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  confusion, depression;

  
  


• 
  

  feeling restless, excited, or agitated;

  
  


• 
  

  seizure (convulsions); or

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects include:

• 
  

  headache, dizziness, drowsiness, shaky feeling;

  
  


• 
  

  drunk feeling;

  
  


• 
  

  vomiting, constipation;

  
  


• 
  

  heartburn, trouble swallowing;

  
  


• 
  

  numbness or tingly feeling;

  
  


• 
  

  dry mouth;

  
  


• 
  

  sweating or urinating more than usual;

  
  


• 
  

  leg pain, tired muscles;

  
  


• 
  

  stuffy nose, ear pain, ringing in your ears; or

  
  


• 
  

  mild itching.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Promacet (acetaminophen and butalbital)?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by butalbital. Tell your doctor if you regularly use any of these medicines.

Tell your doctor about all other medicines you use, especially:

• 
  

  an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate).

  
  

This list is not complete and other drugs may interact with acetaminophen and butalbital. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Promacet resources

• Promacet Side Effects (in more detail)
• Promacet Use in Pregnancy & Breastfeeding
• Drug Images
• Promacet Drug Interactions
• Promacet Support Group
• 0 Reviews for Promacet - Add your own review/rating

• Axocet MedFacts Consumer Leaflet (Wolters Kluwer)


• Cephadyn Advanced Consumer (Micromedex) - Includes Dosage Information


• Phrenilin Prescribing Information (FDA)


• Tencon Prescribing Information (FDA)

Compare Promacet with other medications

• Headache

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and butalbital.

See also: Promacet side effects (in more detail)

Eldoquin Forte

Generic Name: hydroquinone topical (HYE droe KWIN one)

Brand Names: Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Eldopaque, Eldopaque Forte, Eldoquin, Eldoquin Forte, EpiQuin Micro, Esoterica, Esoterica with Sunscreen, Glyquin, Glyquin-XM, Hydroquinone and Sunscreen, Lustra, Lustra-AF, Lustra-Ultra, Melpaque HP, Melquin HP, Melquin-3, Nuquin HP, Solaquin, Solaquin Forte

What is Eldoquin Forte (hydroquinone topical)?

Hydroquinone decreases the formation of melanin in the skin. Melanin is the pigment in skin that gives it a brown color.

Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma.

Hydroquinone topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Eldoquin Forte (hydroquinone topical)?

Before using hydroquinone topical, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not use hydroquinone topical on skin that is sunburned, windburned, dry, chapped, or irritated, or on an open wound. It could make these conditions worse. Wait until these conditions have healed before applying hydroquinone topical. Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Hydroquinone topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

What should I discuss with my healthcare provider before using Eldoquin Forte (hydroquinone topical)?

Do not use hydroquinone topical on skin that is sunburned, windburned, dry, chapped, or irritated, or on an open wound. It could make these conditions worse. Wait until these conditions have healed before applying hydroquinone topical.

Before using hydroquinone topical, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  liver disease; or

  
  


• 
  

  kidney disease.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hydroquinone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Eldoquin Forte (hydroquinone topical)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Hydroquinone topical is for external use only. Wash your hands before and after applying this medication, unless you are treating a skin area on your hand.

Apply the medication to clean, dry skin. Apply just enough medication to cover the affected area. Avoid applying to the unaffected surrounding skin. Rub in the medication gently and completely.

Avoid getting this medication on your lips or inside your nose or mouth. Hydroquinone may cause numbness of these areas. If the medication does get on any of these areas, rinse with water.

It is important to use hydroquinone topical regularly to get the most benefit.

Store hydroquinone topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of topically applied hydroquinone is not likely to cause life-threatening symptoms.

What should I avoid while using Eldoquin Forte (hydroquinone topical)?

Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use hydroquinone topical on sunburned, windburned, dry, chapped, irritated, or broken skin.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Using hydroquinone topical together with benzoyl peroxide, hydrogen peroxide, or other peroxide products may cause a temporary staining of your skin. This staining can usually be removed with soap and water. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Hydroquinone topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Eldoquin Forte (hydroquinone topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using hydroquinone topical and call your doctor if you have severe burning, stinging, or other irritation of your skin after apply the medication.

Less serious side effects may include mild burning, stinging, itching, redness, or irritation of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Eldoquin Forte (hydroquinone topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied hydroquinone. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Eldoquin Forte resources

• Eldoquin Forte Side Effects (in more detail)
• Eldoquin Forte Use in Pregnancy & Breastfeeding
• Eldoquin Forte Support Group
• 0 Reviews for Eldoquin Forte - Add your own review/rating

• Alustra MedFacts Consumer Leaflet (Wolters Kluwer)


• Epiquin Micro Prescribing Information (FDA)


• Esoterica Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Solaquin Forte Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Eldoquin Forte with other medications

• Dermatological Disorders

Where can I get more information?

• Your pharmacist can provide more information about hydroquinone topical.

See also: Eldoquin Forte side effects (in more detail)

Prempro

Generic Name: conjugated estrogens and medroxyprogesterone (Oral route)

Commonly used brand name(s)

In the U.S.

• Activella


• Alesse


• Angeliq


• Estinyl


• Hemocyte


• Loestrin 1/20


• Mircette


• Ortho-Novum


• Prefest


• Premphase

Available Dosage Forms:

• Tablet


• Tablet, Chewable

Uses For Prempro

Conjugated estrogens and medroxyprogesterone are estrogen and progestin hormones. Along with other effects, estrogens help females develop sexually at puberty and regulate the menstrual cycle. Progestin lowers the effect of estrogen on the uterus and keeps estrogen-related problems from developing.

Around the time of menopause, the ovaries produce less estrogen. Estrogens are given to:

• Relieve the signs of menopause (vasomotor symptoms of menopause), such as hot flashes and unusual sweating, chills, faintness, or dizziness.


• Treat inflammation of the vagina (atrophic vaginitis) and of the genital area (atrophy of the vulva) by keeping these areas from becoming too dry, itchy, or painful.


• Prevent the loss of bone that begins at the time of menopause. Keeping bones strong decreases the chance of developing weak bones that easily break (osteoporosis). Estrogen use is most effective when it is taken for more than 7 years while you are getting regular exercise and extra calcium. Protection from bone loss can then last for many years after you stop taking the medicine.

There is no medical evidence to support the belief that the use of estrogens will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during menopause will relieve emotional and nervous symptoms, unless these symptoms are related to the menopausal symptoms, such as hot flashes.

Progestins are not needed if the uterus has been removed by a surgical method called hysterectomy. In that case, it may be better to receive estrogens alone without the progestin.

Conjugated estrogens and medroxyprogesterone are available only with your doctor's prescription.

Before Using Prempro

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Conjugated estrogens and medroxyprogesterone may increase your chance of having a stroke, memory problems, or breast cancer that spreads to other parts of your body.

Pregnancy

Conjugated estrogens and medroxyprogesterone are not recommended for use during pregnancy. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause. Tell your doctor right away if you suspect you are pregnant.

Breast Feeding

Conjugated estrogens and medroxyprogesterone pass into the breast milk. This medicine is not recommended for use during breast-feeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Boceprevir

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Boceprevir


• Felbamate


• Isotretinoin


• Paclitaxel


• Paclitaxel Protein-Bound


• Theophylline


• Tizanidine


• Tranexamic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma or


• Epilepsy or


• Heart problems (congestive heart failure) or


• High blood pressure or


• Kidney problems, severe or


• Migraine headaches—Rarely, water retention caused by conjugated estrogens and medroxyprogesterone may make these conditions worse.

• Blood clotting problems, or history of with previous estrogen use or


• Breast cancer, estrogen-dependent, or history of or


• Breast cancer, or history of or


• Deep vein thrombosis (blood clot in the leg), active or history of or


• Heart attack, active or recent (within past year) or


• Liver disease, including jaundice, or history of or


• Pulmonary embolism (clot in the lung), active or history of or


• Stroke, active or recent (within past year) or


• Venous thromboembolism (clot in the veins), or history of—Conjugated estrogens and medroxyprogesterone should not be used in patients with these conditions.

• Bone cancer or


• Endometrial cancer (cancer of the uterus), active or suspected or


• Fibroid tumors of the uterus—Estrogens may interfere with the treatment of bone cancer, worsen cancer of the uterus, or increase the size of fibroid tumors.

• Changes in genital or vaginal bleeding of unknown causes—Estrogens may make these conditions worse; some irregular vaginal bleeding may be a sign that the lining of the uterus may be growing too much or is a sign of cancer of the uterus lining.

• Changes in vision—This medicine may cause changes in vision; your medicine may need to be stopped if these conditions become worse.

• Diabetes mellitus—Conjugated estrogens and medroxyprogesterone may slightly change the amount of blood sugar for some patients, but for most patients with diabetes, there is no change in blood sugar.

• Endometriosis or


• Gallbladder disease or gallstones, or history of or


• High cholesterol or triglycerides, or family history of or


• Memory loss (dementia) or


• Pancreatitis (inflammation of pancreas) or


• Porphyria (liver problem)—Conjugated estrogens and medroxyprogesterone may make these conditions worse; using estrogens can lower blood cholesterol in many patients with high cholesterol.

• Hypothyroidism (underactive thyroid)—A change in dose of thyroid medication may be needed.

• Low blood calcium, severe—Estrogens should be used with caution in patients with this condition.

Proper Use of conjugated estrogens and medroxyprogesterone

This section provides information on the proper use of a number of products that contain conjugated estrogens and medroxyprogesterone. It may not be specific to Prempro. Please read with care.

Conjugated estrogens and medroxyprogesterone usually come with patient directions. Read them carefully before taking this medicine.

Take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer period of time than your doctor ordered. The length of time you take the medicine will depend on the medical problem for which you are taking conjugated estrogens and medroxyprogesterone. Discuss with your doctor how long you will need to take these medicines.

If you are taking the estrogen or progestin hormones in a certain order (i.e., conjugated estrogens tablets followed by conjugated estrogens and medroxyprogesterone tablets), be sure you know in which order you need to take the medicines. If you have questions about this, ask your health care professional.

Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For conjugated estrogens, and conjugated estrogens and medroxyprogesterone


• For oral dosage form (tablets):
  
  • To prevent loss of bone (osteoporosis) or for treating itching or dryness of the genital area (atrophy of the vulva), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
    
    • Adults—One tablet (containing 0.625 mg conjugated estrogens) once a day on Days 1 through 14; then, one tablet (containing 0.625 mg conjugated estrogens and 5 mg medroxyprogesterone) once a day on Days 15 through 28. Repeat cycle.
    
    
  
  

• For conjugated estrogens and medroxyprogesterone


• For oral dosage form (tablets):
  
  • To prevent loss of bone (osteoporosis) or for treating itching or dryness of the genital area (atrophy of the vulva), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
    
    • Adults—One tablet (containing 0.3 mg conjugated estrogens and 1.5 mg medroxyprogesterone) once a day for twenty-eight days. Repeat cycle. If vaginal bleeding or spotting continues and it is undesired, your doctor may increase your dose to the next highest strength tablet (0.45 mg conjugated estrogens and 1.5 mg medroxyprogesterone). It should be taken once a day for twenty-eight days. Repeat cycle.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Prempro

It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects. Plan on going to see your doctor every year, but some doctors require visits more often.

Although the risk for developing breast problems or breast cancer is low, it is still important that you regularly check your breasts for any unusual lumps or discharge, and report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) and breast examination done by your doctor whenever your doctor recommends it.

If your menstrual periods have stopped, they may start again once you begin taking this medicine. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months.

Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant.

Tell the doctor in charge that you are taking this medicine before having any laboratory test, because some test results may be affected.

You may need to stop taking this medicine before having some kinds of surgery or while your doctor has ordered a long period of bedrest. Talk with your doctor about this.

Prempro Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Healthy women rarely have severe side effects from taking conjugated estrogens or medroxyprogesterone to replace estrogen.

Check with your doctor immediately if any of the following side effects occur:

More common

• Itching of the vagina or genital area


• menstrual periods beginning again, including changing menstrual bleeding pattern for up to 6 months (spotting, breakthrough bleeding, prolonged or heavier vaginal bleeding, or vaginal bleeding completely stopping by 10 months)


• pain during sexual intercourse


• thick, white vaginal discharge

Less common

• Blurred vision


• breast lumps


• chest pain


• discharge from breast


• dizziness


• feeling faint, dizzy, or light-headed


• feeling of warmth or heat


• flushing or redness of skin, especially on face and neck


• headache


• heavy nonmenstrual vaginal bleeding


• pounding in the ears


• severe cramping of the uterus


• slow or fast heartbeat


• sweating

Rare

• Change in vaginal discharge


• pain or feeling of pressure in pelvis


• pain or tenderness in stomach, side, or abdomen


• yellow eyes or skin

Incidence not known

• Abdominal bloating


• acid or sour stomach


• belching


• backache


• full or bloated feeling or pressure in the stomach


• heartburn


• indigestion


• loss of appetite


• pelvic pain


• stomach discomfort, upset or pain


• stomach pain


• swelling of abdominal or stomach are

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal cramps


• back pain


• body aches or pain


• breast pain or tenderness


• congestion


• chills


• cough


• crying


• depersonalization


• diarrhea


• dryness or soreness of throat


• dysphoria


• enlarged breasts


• euphoria


• feeling faint, dizzy, or light-headedness


• feeling of warmth or heat


• fever


• flushing or redness of skin, especially on face and neck


• general feeling of discomfort or illness


• headache, severe and throbbing


• hoarseness


• increase in amount of clear vaginal discharge


• itching


• joint pain


• lack or loss of strength


• mental depression


• muscle aches and pains


• nausea


• pain


• pain or tenderness around eyes and cheekbones


• painful menstrual periods


• painful or difficult urination


• paranoia


• passing of gas


• quick to react or overreact emotionally


• rapidly changing moods


• runny nose


• shivering


• shortness of breath or troubled breathing


• sneezing


• sore throat


• stuffy nose


• stomach discomfort following meals


• tender, swollen glands in neck


• tightness of chest or wheezing


• trouble sleeping


• trouble in swallowing


• unusual tiredness


• voice changes


• vomiting

Less common

• Acne


• bloating or swelling of face, ankles, or feet


• cervix disorder


• crying


• depersonalization


• dysphoria


• euphoria


• increase in sexual desire


• leg cramps


• mental depression


• paranoia


• quick to react or overreact emotionally


• rapidly changing moods


• sleeplessness


• tense muscles


• trouble sleeping


• unable to sleep


• unusual weight gain or loss

Incidence not known

• Abdominal cramping


• bloody or cloudy urine


• bloody vaginal discharge


• difficult, burning, or painful urination


• frequent urge to urinate


• light vaginal bleeding between periods and after intercourse

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Prempro side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Prempro resources

• Prempro Side Effects (in more detail)
• Prempro Use in Pregnancy & Breastfeeding
• Drug Images
• Prempro Drug Interactions
• Prempro Support Group
• 6 Reviews for Prempro - Add your own review/rating

• Prempro MedFacts Consumer Leaflet (Wolters Kluwer)


• Prempro Consumer Overview

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• Atrophic Vaginitis
• Oophorectomy
• Osteoporosis
• Postmenopausal Symptoms
• Primary Ovarian Failure

Veletri

Pronunciation: E-poe-PROST-e-nol
Generic Name: Epoprostenol
Brand Name: Examples include Flolan and Veletri

Veletri is used for:

Treating high blood pressure in the blood vessels of the lungs (pulmonary arterial hypertension [PAH]) to improve exercise capacity.

Veletri is a prostaglandin. It works by relaxing the blood vessels, which increases blood flow to the lungs.

Do NOT use Veletri if:

• you are allergic to any ingredient in Veletri or to a similar medicine (eg, treprostinil)


• you have congestive heart failure caused by severe left-sided heart problems


• you have previously taken Veletri and developed fluid in the lungs (pulmonary edema)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Veletri:

Some medical conditions may interact with Veletri. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Veletri. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide), medicines for high blood pressure, or other vasodilators (eg, minoxidil) because the risk of low blood pressure may be increased


• Anticoagulants (eg, warfarin) or antiplatelet medicines (eg, aspirin, clopidogrel) because the risk of bleeding may be increased by Veletri


• Digoxin because the risk of its side effects may be increased by Veletri

This may not be a complete list of all interactions that may occur. Ask your health care provider if Veletri may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Veletri:

Use Veletri as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Veletri is given as an intravenous (IV) infusion. If you will be using Veletri at home, a health care provider will teach you how to use it. Be sure you understand how to use Veletri. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Veletri must be mixed with a certain type of solution. Do not use any other type of solution to mix Veletri. After Veletri has been mixed, do not combine or mix it with any other solutions or medicines. Contact your doctor or pharmacist if you are unsure which type of solution to mix Veletri with.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Veletri, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Veletri.

Important safety information:

• Veletri may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Veletri with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not suddenly stop using Veletri. You may experience a recurrence of PAH symptoms (eg, shortness of breath, dizziness, weakness). Discuss any questions or concerns with your doctor.


• Veletri may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Veletri should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Veletri while you are pregnant. It is not known if Veletri is found in breast milk. If you are or will be breast-feeding while you use Veletri, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Veletri:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations (eg, burning, numbness, tingling); agitation; anxiety; back pain; bleeding, pain, redness, or swelling at the injection site; constipation; diarrhea; dizziness; flu-like symptoms (eg, mild fever, mild chills, muscle aches); flushing; headache; loss of appetite; muscle, bone, joint, or jaw pain; nausea; nervousness; stomach pain or upset; sweating; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or dark urine; chest pain; dark, tarry, or bloody stools; fainting; fast, slow, or irregular heartbeat; light-headedness; new or worsening shortness of breath; pale skin; severe or persistent dizziness; skin ulcers; symptoms of infection (eg, fever, chills, sore throat, cough); tremor; unusual or increased bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Veletri side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fainting; flushing; headache; light-headedness; nausea; rapid heart rate; severe or persistent dizziness; vomiting.

Proper storage of Veletri:

Veletri is usually handled and stored by a health care provider. If you are using Veletri at home, store Veletri as directed by your pharmacist or health care provider. Keep Veletri out of the reach of children and away from pets.

General information:

• If you have any questions about Veletri, please talk with your doctor, pharmacist, or other health care provider.


• Veletri is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Veletri. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Veletri resources

• Veletri Side Effects (in more detail)
• Veletri Use in Pregnancy & Breastfeeding
• Veletri Drug Interactions
• Veletri Support Group
• 0 Reviews for Veletri - Add your own review/rating

• Veletri Prescribing Information (FDA)


• Veletri Advanced Consumer (Micromedex) - Includes Dosage Information


• Veletri Concise Consumer Information (Cerner Multum)


• Epoprostenol Prescribing Information (FDA)


• Epoprostenol Sodium Monograph (AHFS DI)


• Flolan Prescribing Information (FDA)

Compare Veletri with other medications

• Pulmonary Arterial Hypertension